My Research

I am a bioinformatician and research associate at the Department of Bacteria, Parasites and Fungi at Statens Serum Institut, Denmark. My main research interests are the molecular epidemiology and host-pathogen interaction of opportunistic pathogens and I enjoy studying them using genomics and bioinformatics approaches. With a focus on melting together data and knowledge from various disciplines, my research approaches modern epidemiological challenges in a holistic One-Health perspective.

My background is in evolutionary biology from the University of Zürich and ETH Zürich, and I have done my PhD in Evolutionary dynamics and human epidemiology of LA-MRSA at the University of Copenhagen, Denmark and the Department of Bacteria, Parasites and Fungi at Statens Serum Institut, Denmark, where I since then am employed as a research associate.

Short CV

2015 - present: Department of Bacteria, Parasites and Fungi, Statens Serum Institut (SSI), Copenhagen, Denmark: Research associate and PhD student.

2011 - 2013: Swiss Federal Institute of Technology (ETH) Zürich, Switzerland: Master of Science ETH in Biology with major in Ecology and Evolution, 22.11.2013

2005 - 2008: University of Zürich (UZH), Zürich, Switzerland: Bachelor of Science UZH in Biology, with focus on evolution, ecology and environmental science, 8.12.2008

ORCiD

0000-0002-0372-128X

Publications

Jesper Larsen, Claire L. Raisen, et al. (2022) Emergence of methicillin resistance predates the clinical use of antibiotics. Nature 602, 135–141 (2022)
https://dx.doi.org/10.1038/s41586-021-04265-w

Peter Bager et al. (2022) Risk of hospitalisation associated with infection with SARS-CoV-2 omicron variant versus delta variant in Denmark: an observational cohort study. The Lancet Infectious Diseases 2022;22 :967–76
https://dx.doi.org/10.1016/s1473-3099(22)00154-2

Marc Stegger et al. (2022) Occurrence and significance of Omicron BA.1 infection followed by BA.2 reinfection. medRxiv 2022.02.19.22271112
https://dx.doi.org/10.1101/2022.02.19.22271112

Raphael N. Sieber, Urth, T., Petersen, A., Møller, C., Price, L., Skov, R., Larsen, A., Stegger, M., Larsen, J. (2020). Phage-Mediated Immune Evasion and Transmission of Livestock-Associated Methicillin-Resistant Staphylococcus aureus in Humans. Emerging infectious diseases 26(11)
https://dx.doi.org/10.3201/eid2611.201442

Raphael N. Sieber, Robert L. Skov, Jens Nielsen, Jana Schulz, Lance B. Price, Frank M. Aarestrup, Anders R. Larsen, Marc Stegger, Jesper Larsen. 2018. Drivers and Dynamics of Methicillin-Resistant Livestock-Associated Staphylococcus aureus CC398 in Pigs and Humans in Denmark. mBio 9:e02142-18.
https://mbio.asm.org/content/9/6/e02142-18

Jesper Larsen, Andreas Petersen, Anders R Larsen, Raphael N Sieber, Marc Stegger, Anders Koch, Frank M Aarestrup, Lance B Price, Robert L Skov, for the Danish MRSA Study Group. 2017. Emergence of Livestock-Associated Methicillin-Resistant Staphylococcus aureus Bloodstream Infections in Denmark. Clinical Infectious Diseases, Volume 65, Issue 7, 1 October 2017, Pages 1072–1076.
https://academic.oup.com/cid/article/65/7/1072/3858784

Full publication list

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Full CV with focus on science (217Kb, last updated Oct 2020)